Addiction to morphine and heroin can be blocked, according to research released on Wednesday which could prove a major breakthrough in treating addicts and in pain relief treatments. Researchers at the University of Adelaide in Australia worked with colleagues at the University of Colorado in the United States to pinpoint a key mechanism in the body's immune system that amplifies addiction to opioid drugs.
"Our studies have shown conclusively that we can block addiction via the immune system of the brain, without targeting the brain's wiring," said Mark Hutchinson from Adelaide's School of Medical Sciences.
"Both the central nervous system and the immune system play important roles in creating addiction, but our studies have shown we only need to block the immune response in the brain to prevent cravings for opioid drugs."
The results, to be published Thursday in the Journal of Neuroscience, reveal that laboratory studies showed that the drug known as plus-naloxone, which is not yet in clinical use, will selectively block the immune-addiction response.
The researchers said that opioid drugs such as morphine and heroin bind to immune receptors in the brain known as TLR4 which then act as amplifiers for addiction, ramping up the "reward" effect of drugs of abuse to a high degree.
The new drug automatically shuts this effect down, Hutchinson said.
"It really reduces the reward level down to the equivalent of food, sex, and hugs," he told AFP.
Professor Linda Watkins, from the Center for Neuroscience at the University of Colorado, said the work fundamentally changed understanding about opioids, reward and addiction. --- Keep reading this story
Addiction to heroin can be blocked, research says.
If you’ve seen The Dark Knight, you likely know we’re talking about the scenes that show the Joker issuing threats and warnings through recordings done with a camcorder.
The most recognizable line to come from these scenes is when the Joker says "Tonight, people are going to die." Chris Nolan trusted Heath Ledger with these so much that he wasn’t even present during some of the last shootings of the scenes.
Ledger shot and directed them almost completely by himself. The first video had a bit more help. The lighting guy and the sound guys came in to set everything up, but ultimately Nolan was so impressed that after the first shoot he handed the camera to Ledger and said “do whatever you want.”
Apparently, Ledger got so into it that every single take he did was different from the last. In making The Dark Knight, Nolan didn’t want to make a bland sequel and strived to only do what works.
So devoted was Nolan to this film that there isn’t a single deleted scene. He only shot scenes that had at least three reasons to be in the film to ensure that everything would be equally important and nothing would waste time.
These type of pictures seem to come up from time to time...but could this be the "real" Banksy after all? Something called the Brian Sewell Art Directory claims to know the truth. Search Banksy on Google and this picture is the first thing that comes up. Is it fake? Whats up!
from Brian Swell Art Directory:
"Banksy Revealed! We have an exclusive official picture of Robert Banks.Unlike Peter Dean Rickards dodgy fake pictures, we have had this picture
The gun control debate rises anew in the wake of another mass shooting, but mental health treatment should receive the same critical attention and maybe more.
We're past the point of reversing our nation's gun culture, but it's not too late to better handle the psychological problems often at the root of such senseless violence. We need to ask some serious questions about how we treat the mentally ill, how we pay for that care and how we change a dismissive attitude toward a problem that can be solved. We can start with our elected officials. Do something about it!
It really is a numbers game. Play the numbers, roll with the punches. It’s a roller coaster, ups and downs, baby. "When you’re up, it’s never as good as it seems and when you’re down it seems like you’ll never get up again." You will.
"Good things come to those that wait". Not this time. Good things come to those that act. The 3-second rule works on many levels.
In general, it is bad form to apologize. For anything. You can admit you were wrong, you can offer to make things right, but don’t apologize.
There is no such thing as overconfidence. There is such a thing as taking yourself too seriously, however.
Do not ask permission to do or say anything. Never ask a woman if you can kiss them, hug them, hold them, etc.
Agreeable is boring.
Jealousy is a "let’s just be friends" best friend.
. Never ask questions that are designed to find out what she thinks of you.
A fireplace is a worthwhile investment.
You must lead. Even if you don’t know where you’re going. Make it an adventure. Take her hand and lead.
Life isn’t fair and dating is a part of life. Dating, dealing with women, isn’t and isn’t supposed to be fair. Get over it.
A woman will test you and keep on testing you. Don’t get too comfortable. Stay on your toes.
NEED A QUICKIE?
QUICK ADVICE FOR DUDES THAT HAVE NO CLUE ON DATING. READ UP!